Tuberculosis continues to be a health problem both globally and in Colombia. According to the report issued by the World Health Organization (WHO) in 2017, it is estimated that TB is the ninth worldwide cause of death and the first due to infectious diseases, above HIV / AIDS. In Colombia, it has been shown that there are many barriers that have contributed to the reduction of the possibilities of making a diagnosis and timely treatment; conditions that must necessarily be present to achieve an effective control of the disease. Therefore, the objective of the present study is to identify the different barriers that appear in a patient diagnosed with tuberculosis during treatment in Colombia in the years 2007 to 2017. It corresponds to a systematic review of the literature on the different barriers found in a patient diagnosed with tuberculosis during their treatment in bibliographic databases of national and international importance. The sample consists of 30 original articles, review, and reflection that mention the different barriers that occur in a patient diagnosed with tuberculosis in Colombia between the years 2007 to 2017. The results of the study show that to achieve a strong impact on the control and eradication of tuberculosis, aspects such as the academy and the teaching-learning process of public health and its technical and administrative aspects must be strengthened, as well as encouraging the promotion of healthy lifestyles with actions aimed at the active search for respiratory symptoms, a checklist is designed to perform the patient immediately be diagnosed with the pathology to detect possible barriers and intervene to enable the patient to comply with the treatment.