Anthropogenic activities have fragmented natural areas, reducing connectivity between the ecosystems, so that wild species are pressured to adapt to a new landscape and, therefore, look for resources in agricultural productions that are adjacent to their habitat, leading to conflicts between wildlife and producers. This conflict has been reported with large felines and the Andean bear (Tremarctus ornatus), the reason why it was proposed to determine the conflict of the Andean bear with anthropic activities, especially agriculture, and generate management strategies to reduce this conflict in Zetaquira, Colombia. For this purpose, 20 plots of land were searched in three villages in the municipality, using a signal interpretation matrix, a thematic interview, and a characterization of the distance from water sources and natural zones to the attack areas. Attacks by the bear were found in 60% of the sampled properties, being the months from January to April, in the years investigated, in which 71.4% of the attacks were registered. Based on this information, a strategy was created, taking into account the context of Zetaquira, to reduce the conflict.