Background: The corneal ulcer of mycotic etiology caused by Lasiodiplodia theobromae is an infrequent pathology with less than 50 cases of ocular infection by this pathogen reported in the literature. Objective: To present a case of a rare pathology, make a brief literature review, and discuss the chosen treatment that was favorable. Study design: Case report Case summary: We present the case of a patient treated at the Hospital Universitario de Santander (HUS) during the years 2015 - 2017 with a history of ocular trauma with plant material who developed fungal corneal ulcer by Lasiodiplodia theobromae , which was confirmed using microbiological analysis of the corneal smear. Treatment with a combination of antifungals was established with a satisfactory final result Conclusion: L. theobromae is an opportunistic pathogen. The importance of early diagnosis in these cases, which requires a high index of suspicion in patients with plant trauma, with the identification of the etiological agent lies in avoiding or minimizing irreversible consequences through the establishment of an opportune treatment.