In the last 25 years, growing importance has been given to technology production and other forms of knowledge creation, that is produced by universities throughout the world and has commercial value. In this paper, the last ten years’ performance of Chilean universities as producers of knowledge with commercial value, and industrial applications, as well as restricted to intellectual property, are evaluated. Industrial patents, models of utility and industrial designs are considered as quantifiable referents. A synthesis of the way the main Chilean universities are incorporating this aspect of the academic work is presented. Finally, the relative results observed in Chile are compared with those obtained in the USA and Europe.