Leishmaniasis is a vector-borne disease caused by protozoan parasite, it is transmitted by Lutzomiya. It is considered as a neglected disease by WHO, millions of people are exposed to contract the disease. Colombia, presents meteorological variations, with some climatic phenomena such as El Niño and La Niña in some periods of time, which may be associated with an increase in the cases of mucosal leishmaniasis (LM) and cutaneous leishmaniasis (LC). Materials and methods: Ecological study of time series was carried out, from a secondary source of information. The objective was to determine the relationship between LM and LC incidences and the variation of temperature and the variation of precipitation, also and El Niño y La Niña during the period between 2007 and 2015. The information used was obtained from SIVIGILA, DANE and IDEAM. A multilevel Poisson regression was performed to calculate the incidence rate ratio (IRR). Results: The variation of precipitation with a delay of three months and La Niña with two months of delay were associated with the decrease in the incidence rate of LC (IRRa 0.97 CI95% 0.95 - 0.99; IRRa 0.80 CI95% 0.78 - 0.83) and El Niño was associated with an increase in the incidence rate (IRRa 1.27 CI95% 1.23-1.32). Additionally, the variation of temperature with a month of delay was associated to the decrease of the LM rate (IRR 0.8 CI95% 0.68 - 0.95); on the contrary, the variation of the precipitation with three months of delay, increased the LM rate (IRR 1.21 CI95% 1.03 - 1.42). Conclusions: This information could use to improve the ability for planning specific prevention and mitigation strategies, through the generation of early warnings using public availability information.