Climate change affects territories, their inhabitants and natural resources. Particularly in the department of Antioquia, which concentrates most of its territory in the Colombian Andean zone, climate change is a latent threat that can cause life zones distribution changes, causing an alteration of biological and ecosystems cycles and relationships which keep natural equilibria. Based on projects developed by Antioquia’s Central Regional Autonomous Corporation (Corantioquia), which aim to mitigate and adapt the territory and its inhabitants to climate change effects, and based on climate change scenarios provided by the Institute of Hydrology, Meteorology and Environmental Studies (Ideam) and the life zones information owned by the Corporation, a calculation and analysis method was proposed in order to determine possible paramo and wetland in the Corporation’s jurisdiction would not present significant changes in terms of precipitation and temperature variations and therefore to 2040 they might not have threats of disappearance, although by anthropic uses they are seriously threatened. On the other hand, tropical dry forest would undergo changes based on the projections of these scenarios, generating environmental conditions similar to those present in wet forests. Based on these results, it can be concluded that strategic ecosystems management strategies are necessary in order to guarantee the continuous provision of ecosystem services to human communities.