Through what Daniel Feirstein defines as social practice genocide, will analyze the progressive and systematic social reorganization that has been brewing in the municipalities of Remedios and Segovia in Northeast Antioquia, as account for practical genocidarias carried out against social organizations, political organizations and in general against any person that embodies or may come to embody some kind of autnomy or resistance against organi- zations outside the law as the paramilitaries and guerrillas in the region, agents of the State as members of the national army or at cross purposes of mega-projects for the exploitation of the natural resources tax in the region by large capital. This situation is try to make a brief historical processes carried out in the municipal- ities of Remedios and Segovia, an analysis roughly both legal and theoretical as to what means the Genocio and social practice genocide, extermination and systematic genocide to finish carrying out a diagnosis on the processes of symbolic and social reorganization that come from social practice genocide in the region of the north- eastern Antioquia presented