The Gleason score as a histological staging tool in patients with prostate cancer plays an important role on prognosis determination and the disease behavior, which is a factor that must be taken into account at the moment of the taking of decisions regarding the treatment to be performed. However, despite the reliability of Gleason score with respect to the same specimen, the correlation between the result of the prostate biopsy and the surgical specimen of the radical prostatectomy is variable. Objective: Determine the concordance between the Gleason score of the transrectal prostate biopsy and the Gleason score of the radical prostatectomy. Materials and methods: Concordance study. 90 records of radical prostatectomy pathology between 2014-2018 was carried out. All patients had to have a prostate biopsy prior to radical prostatectomy, and both procedures performed at Hospital MIlitar Central. Cohen's Kappa correlation was used to determine the agreement between the variables. Results: Cohen's Kappa concordance index for the gleason score in the risk group was 0.154 and weighted Kappa was 0.379, implying a poor and weak concordance as a result of the anatomopathological result of the transrectal prostate biopsy with radical prostatectomy. Conclusions: In general, the reliability of the cycle score of needle biopsies to predict the final pathology was weak. However, it was not determined that this concordance is significant at the time of making decisions in the management of the patient. upgrading and overgrading degree are comparable with world reference centers and the therapeutic decision takes into account this difference and other clinical factors that allow for an adequate treatment choice.