Glucose dependent insulinotropic polypeptide (GIP) is a gut hormone released mainly by a nutritional stimuli mediated by oral ingestion. It has been related to the development of T2D and obesity, conditions which are on the list of the leading causes of death. The objective of this study was to find literature that reported the modulation of GIP’s gene and also to investigate the functions of GIP during normal conditions and during T2D and obesity. Available studies can be found in PUBMED, SCIENCEDIRECT, MEDLINE. There were 51 of studies selected that demonstrated strong evidence about the topic. Evidence shows that GIP on normal states has the function of promote insulin secretion and adipose tissue redistribution. While in type 2 diabetes it’s been found that it does not work due to the inactivity of its receptor on beta cells. During the obese state, GIP contributes to the inflammatory state through the activation of cytokines like resistin, IL-1 and IL-6 , and also decreases the concentration of adiponectin. One of the main findings of this study was the fact that glucose has effects on GIP’s secretion independently of the transcription factor PPARβ/δ, the use of an antagonist of PPARβ/δ wouldn’t affect the essential functions of GIP, and could be a possible treatment in the long term against T2D and obesity.