Lymphoma is the main cancer type and the most related with mortality associated with HIV. HIV* patients tend to develop aggressive B lymphomas, with a risk between 60 and 200 times for Non-Hodgkin’s lymphoma development in contrast with HIV population. There is evidence that the impairment of the immune system due to HIV disrupts B cell homeostasis, and this favours uncontrolled B cells proliferations, secondary infections by oncogenic viruses, like Epstein Barr virua, and a high level of circulating viremia. The general objective of this study was to analyse the presence of circulating clonal populations of B lymphocytes in peripheral blood with characteristics of neoplastic B cells in HlV patients in different clinical stages of the disease. Peripheral blood of 238 HIV* patients from the San Ignacio University Hospital in different clinical stages. This study describes for the first time that 31,9% of patients have some alteration in transitional B lymphocytes, mature B lymphocytes and/or plasma cells. Kappa/Lambda ratio. Additionally, 8% of the patients have some population considered clonal by the altered Kappa/Lambda relationship. In these patients have aberrant immunophenotypes, including overexpression and underexpression of various B-lineage associated antigens and higher EBV viral load. These findings together show that chronic HIV-induced activation has important effects on leukocyte populations and the immunophenotypic characteristics of B populations with clinical impact.