Within the framework of the National Policy for the Integral Management of Biodiversity and its Ecosystem Services, the payment for ecosystem services (PES) has been proposed as a favorable tool for the conservation of protected areas in the country, particularly in territories that currently stand out as especially vulnerable to climate change, such as the Amazon. However, the approach to ecosystem services in the context of protected areas that overlap with indigenous territories should also consider additional focus elements such as cultural principles of the use of nature, cultural systems of land use and intercultural dialogue, as well as a holistic view of the territory and the reciprocal and grateful interaction between indigenous societies and nature. The case study confronts the elements of a typical PES scheme within the context of the Cahuinari National Natural Park and the PANI (Piine Aiiyveju Niimue Iachiuma, which means God of the Center and his grandchildren, in Mirana language) indigenous Association. In this study, we analyze the socioecological risks on the design of the PES scheme and reflect on the stages of preparation, negotiation, motivation and retribution that must be agreed among the actors involved. The exercise also proposes some guidelines for the designing of an agreement to reach the conservation goals of the area and the objectives of indigenous life plans from an integrated point of view.