Innovation is recognized today as one of the most important development factors for both organizations and countries. When it comes to promoting the constant growth of innovation in organizations, one of the aspects that is determinant in the specialized literature is everything related to the human factor and the influence of human resources in the success of it. The present research focuses on the relationship between human resources practices and innovation, from the case study in the organization Sumicol S.A.S. This relationship is studied through the application of bivariate statistics and a model of structural equations under the PLS method. In general it was found that there is a positive relationship between human resources practices studied and innovation, evidencing the influence of performance evaluation on innovation outcomes, and an important relationship between training and development practices with remuneration and rewards, and of the latter with performance evaluation.