Pseudomonas aeruginosa is a gram-negative bacteria, possesses a great adaptability to hostile environments, one of them is the clinical environment, where it has emerged as a fearful germ which performs a leading role in patients who present bloodstream infections, due to its development resistance mechanisms to different antimicrobial it makes therapeutic management complex, increases mortality and morbidity, hospital stay and health care expenses for these patients are high. A systematic review of available literature was performed to establish the current status of antimicrobial management of bloodstream infection by Pseudomonas aeruginosa.