Metabolic syndrome involves the association in the same individual of dyslipidemia, Diabetes Mellitus 2 or glucose intolerance, hypertension and overweight or obese. The insulin resistance plays a central role in the genesis of this syndrome and to be causing the start of the process of atherosclerosis. This coupled with the loss of the protective effect of estrogen during menopause can lead to the formation of atheromatous plaque and secondly the development of vascular diseases cardiocerebro and its possible consequences. The aim of this study was to determine the prevalence of metabolic syndrome in postmenopausal patients and possible related factors, using a cross-sectional study type, through review of medical records of patients who attended the Gynecological Endocrinology in Central Military hospital between March 13, 2013 and December 31, 2014. Results: A total of 81 postmenopausal women were included in the study. The mean age was 58.6 ± 10.3 years. The average age of the last menstrual period was 10.3 years. The prevalence of metabolic syndrome was 23.5%. Personal history of arterial hypertension in 44.4%, 25.6% diabetes mellitus, hypercholesterolemia and hypertriglyceridemia in 60.0% was found in 46.9% of cases. Was also documented that 50% have levels of HDL <50mg / dl, triglycerides 46.9% ≥150mg / dl, 44.4% blood pressure ≥130 / 85mmHg, 25.6% glucose 100 mg / dl and 22.2% BMI ≥30. It showed that 82.7% of patients have some type of dyslipidemia as a final diagnosis. 59.2% of the study population were overweight or obese, of which 35.8% were overweight and 23.4% obese. The bivariate analysis in search of risk factors showed a statistically significant difference with socioeconomic <3 strata (p = 0.011), family history of hypertension (p = 0.117) and diabetes mellitus (p = 0.157). According to the final multivariate model, the variable that increase the risk of metabolic syndrome was socioeconomic status (OR 4.7, 95% CI 1.03 - 22.11). In conclusion, the metabolic syndrome is a disease of high presentation menopausal patients with increased risk in patients of low socioeconomic status and history of underlying conditions with hypertension and diabetes mellitus that facilitate the establishment of the same, so these patients benefit from early interventions and a multidisciplinary approach for the prevention of cardiovascular disease secondary to it.