Deterioration of neurocognitive function is one of the most common complications of the infection by human immunodeficiency virus. Studies have been developed to address its diagnosis and management, seeking to improve the quality of life of these patients. This work, through the application, identification and analysis of three functions of public health, makes a description of neuropsychological status of patients diagnosed with HIV/AIDS attending the special program of the “Hospital Occidente de Kennedy”, to call the attention to the issue, and to propose specific recommendations in the population referred. Methodology Descriptive case-series study, conducted in patients diagnosed with HIV, attending outpatient special program of “Hospital Occidente de Kennedy”. 1) A review of 45 clinical records and databases of the program was conducted to obtain information from demographic and clinical data of patients and perform characterization of this population. 2) Neuropsychological tests were applied, to the patients who agreed to participate in the study, to assess 5 cognitive domains that are affected more frequently in patients with HIV and 2 tests to assess functional capacity. Results Patients belong to the population that is not affiliated to the general social security system, have low education, and mostly have no formal jobs or are unemployed. Of the 8 patients assessed by neuropsychological tests, all have some type of cognitive impairment; domains that showed more commitment within the group of 8 patients were: evaluated attention / working memory, memory and language. Conclusion Patients diagnosed with HIV/AIDS attending the program mentioned, have a number of features that add, to be considered as a vulnerable population requiring special attention. The results of this study suggest that mechanisms should be established to assess the cognitive profile of all members of the program and should be implemented measures to treat participants in the study