El sindrome DRESS (Reaccion a farmacos con eosinofilia y sintomas sistemicos) es una toxidermia sistemica poco frecuente, caracterizada principalmente por rash, fiebre, disfuncion hepatica y eosinofilia. Se puede presentar luego de la exposicion a ciertos farmacos, con una elevada mortalidad entre el 10% y 30 % de los casos. El diagnostico no es tan sencillo, por la amplia variedad en la presentacion clinica y pruebas de laboratorio. Generalmente, las enfermedades de base y comorbilidades afectan el curso natural y empeoran el pronostico. Se presenta el caso, de una nina que desarrolla sindrome de DRESS durante su hospitalizacion en cuidado intensivo. Summary DRESS Syndrome in a child with brain tumor. DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a rare systemic toxidermia, characterized mainly by rash, fever, hepatic dysfunction and eosinophilia. It can occur after exposure to certain drugs, with an elevated mortality between 10% and 30% of cases. Because of the wide variety of clinical presentation and laboratory tests, the diagnosis is not easy. Generally, the underlying diseases and comorbidities affect the natural course and complicate the prognosis. We present the case of a girl who develops DRESS syndrome during her hospitalization in intensive care. Key words: DRESS syndrome; drug hypersensitivity; carbamazepine.