Objective. Relate disability and health-related quality of life in adults with disabilities in the city of Barranquilla, Atlantico (Colombia, 2017). Materials and method. Descriptive study of correlational scope with 125 participants with disabilities over 20 years of age who had been permanently limited for more than six months. The WHODAS 2.0 questionnaire was used to assess disability and the WHOQOL-Bref to establish the health-related quality of life of the population with disabilities. Results. 51.2% of the participants were men with a mean age of 45.63 ± 17.9176 years. The mean disability was 18.96 ± 12.8911 points; Of the areas evaluated by WHODAS 2.0, the one with the highest average score was the area of participation in society 25.26 ± 19.5057 and the area with the lowest average was personal care with 8.48 points. In quality of life, it was found that the domain of interpersonal relationships (72.66 ± 16.1409 points) was the best perceived. In the relationship between sociodemographic variables and disability, it was found that age, age ranges and occupation presented a statistically significant relationship with the areas of mobility and personal care and with all the domains of quality of life related to health. When relating the clinical variables and disability, it was found that the areas of mobility, personal care and the end of disability presented a statistically significant association with the majority of clinical variables and when establishing the relationship between disability by areas and end with health-related quality of life By dimension, a significant and inverse relationship was evidenced with all HRQOL domains; the strength of these associations was mostly moderate. Conclusion. Occupation is a variable that influences the degree of disability, the less degree of limitation, the better the perception of quality of life and vice versa.