The purpose of this study is investigating the relationship between Strategic Orientation and Managers’ decision making in Manufacturing and Petrochemical Companies of accepted in Tehran Stock Exchange. The current research in terms of subject is descriptive – correlational research and in terms of purpose is applied research and in terms of method by survey research has been done. The population of this study is Manufacturing and Petrochemical Companies of accepted in Tehran Stock Exchange that it is around 280 companies. According to data collected, the research is occasional discussion. In this regard, statistical sample was selected out of 134 companies; the sampling has been used as simple random method. A method for collection data was librarian field method and the main instruments were standards questionnaires. Since significant level is smaller than 0/05, the result is that there is significant relationship between strategic orientation and manager’ decision, also, since correlation coefficient is 0/754 for two variables, it can be claimed that the relation between strategic orientation and managers’ decision making is evaluated well. Determination coefficient is 0/329 and this value shows that 32% of changes for manager’ decision are dependent to strategic orientation.