5Z-7-oxozeaenol is a molecule belonging to the family of the resorcylic acid lactones (RALs). These molecules have great potential biological activity. The interest in the study of 5Z-7-oxozeaenol arises from its strong and selective inhibitory activity of the TAK1 proteins (IC50=8.1nM), which makes it a potential anti-inflammatory and anti-cancer agent. So far, 6 different total synthesis have been reported. The key steps in these synthesis are the formation of a Z alquene moiety, crucial for the molecule’s biological activity, and a 1,2-diol anti. The present work focused on the synthesis of the first precursors of this molecule using a new synthetic route. The first precursor was obtained through a Michael reaction of the 1,3-propanodithiol and methyl propiolate. During the optimization process, it was determined that factors such as the nucleophilicity of the base used and the presence of water in the reaction media affected the yield of the reaction significantly. The use of NaOMe and THF directly distilled into the reaction flask gave the highest yields. Afterwards, the synthesis of a ketone from an ester was carried out using a Grignard reaction. Controlling the amount of equivalents of the Grignard reagent was fundamental for optimizing the selective formation of the ketone. The corresponding alcohol was obtained by reducing the ketone previously obtained under classic conditions using NaBH4. However, the synthesis of the alcohol was optimized by reducing the ketone directly in the Grignard reaction flask. This was accomplished by adding the NaBH4 directly into the Grignard reaction, which gave yields of up to 76%. Finally, experiments to deprotect a diethyl acetal under acidic conditions were carried out using different kinds of acids. However, it was not possible to isolate the desired aldehyde.