Autism transcends the limits of the Pediatric Specialty; it is considered the greatest mental disorder of childhood, so these patients need a great dedication of their families and society to raise their quality of life. Its diagnosis is clinical and its prognosis depends, to a great extent, on early diagnosis and timely multidisciplinary and intersectoral treatment. It was considered of interest to comment the main clinical aspects of the disease to contribute to its rapid recognition from the primary level and its integral attention, as well as the most important aspects for its stomatological attention in order to improve its oral and general health.