The La Salina Fault, located in a region of high seismicity was studied in an area of 294 km2 in the Santander Department, it's defined as an inverse fault. In general it doesn't present clear morphological or actual activity evidences. In the area of the Hydroelectrical Project of the Sogamoso River by ISAGEN SA., a six stations seismic network was installed in an area near to the fault. During 124 days, 2.367 seismic events were evaluated; from these, 339 acceptable quality events were chosen for doing maps and profiles. Most of the seismicity is related to the Bucaramanga Nest, other 131 seismic events ware related to the mapped faults. Only two events were related to the La Salina Fault, defining a indicating low activity.