The world is being globalized and Colombia has not been immune to this process as has signed free trade agreements progressively impacting the productive sectors. In which the country has bet on developing different sectors of the economy. Therefore, the aviation sector cannot be indifferent to this opportunity to offer even more capabilities and through the management of technology and innovation. This research was conducted in Santiago de Cali Valle del Cauca Colombia, between 2012 and 2015, in which businessmen, the government, universities and Colombian Air Force participated, hence the purpose of this investigation was to design a model of Technology and Innovation Management to develop the Aerospace Cluster of Valle del Cauca (Col), for it was necessary to perform a diagnosis of the current state of the cluster, then the simulation model was conducted, and finally the structure of the model. Quantitative and qualitative method was carried out in the methodological design of the research, descriptive-explanatory and transactional type of research, the unit of analysis are the actors involved in the cluster since 2012. The quantitative analysis was performed by processing the data in the statistical package SPSS V.22 using techniques of descriptive and inferential statistical analysis. At the same time IT .V.6.1 Atlas program was used as tool in order to deepen the contents and explaining them. However, quantitative data by itself does not show its usage as a qualitative tool. Among the most significant results is to improve and implement the key variables of organizational development success, competitive management, technology and innovation and with the support and commitment of government, academia, business management. We conclude that applying the model management strategies can strategically position, generating competitive advantages according to the measures proposed for its operation for their development and positioning in the national and international level, achieving excellence in Cluster Management Aerospace Valle del Cauca.