The use of stem cells therapy in oral and maxillofacial surgery is a developing field, which includes management of osseous defects, distraction osteogenesis, implants, TMJ reconstruction, and cleft palate cases. Clinical reports regarding the utilization of stem cells in clef lip surgery are lacking. Since the efficacy of stem cells as tissue inductor in cleft lip and their role in wound healing are not well documented, we aimed at reporting a case where stem cells were used as coadyuvant in cleft lip surgery. The efficacy of these cells as tissue inductor and their role in wound healing are discussed.