Introduction Even though it has been well documented that work activity has a negative impact on the mental integrity of workers, by causing stress and occupational diseases, it can also improve their emotional and cognitive processes by fostering their subjectivity through creation and action processes, as the Work Clinics (“ Cliniques du travail ”; D. Lhuilier, 2006) have shown. These perspectives include a set of theoretical considerations which modify the methodological approach to the psychosocial conditions at work. In the first instance, we think that it is not possible to discuss working situations without a previous understanding of the worker as an active subject who continuously transforms them. In addition, we think that the real activity (“ le travail reel ”; Y. Clot, 2008) of a worker is not limited to a set of formally specified functions, nor even to his observable behavior, because it also includes everything the worker wishes he could have done better, but was out of his possibilities (“ reel de l’activite ”; Y. Clot, 2008); as well as all conflicts resulting from a changing environment. This means that the activity, as a unit of analysis, requires interpretative methods. These theories might be suitable for Colombia, where labor market deregulation has changed the working conditions in the last three decades by creating a conspicuous segmentation among health workers. In Bogota, 80% of them have informal employments; and thus, they lack many social benefits. These type of ‘flexible’ jobs may have an impact on the mental integrity (S. Martinez, 1997) of workers because of the differences on work organization and how people understand, recreate and accept their duties; despite precariousness and disagreements. With that in mind, we consider that Work Clinics may provide an effective approach to have a better understanding of the relation between activity and mental integrity; always based on subjectivity. Objective The objective of this research was to analyze the professional activity and its implications on mental integrity. We organized a series of sessions along with eight health workers of the Bogota District Health Department. In some of the sessions only researchers were present, while in others, both researchers and other workers attended. We used semi-structured interviews and Work Clinics methods as Instructions to one’s double ( L’instruction au sosie : Clot, 2008), to provide the opportunity to discuss about the tasks they face on a daily basis; as well as the obstacles and strategies they establish to deal with them. These narratives were analyzed in accordance with the perspectives of the Work Clinics and the Health Social Determination (J. Breilh, 2003). Results Preliminary results suggest that, in order to handle conflicts at work, workers establish individual and collective strategies, many of them unintentionally, even as it becomes increasingly difficult to maintain cooperation amid current employment conditions. These collective strategies are widely important because they fill the shortcomings that stem from the lack of formally specified functions. In addition, conflicts at work may not only be related to microstructural reasons (e.g. lack of procedures), but also macrostructural politics (e.g. local government priorities). Finally, it is necessary to understand that professional activity and subjectivity are complex constructs that are always best analyzed within a sociohistorical context.