This paper presents a fault injection tool and methodology for performing Single-Event-Upsets (SEUs) injection campaigns on Commercial-off-the-shelf (COTS) microprocessors. This method takes advantage of the debug facilities of modern microprocessors along with standard GNU Debugger (GDB) for executing and debugging benchmarks. The developed experiments on real boards, as well as on virtual machines, demonstrate the feasibility and flexibility of the proposal as a low-cost solution for assessing the reliability of COTS microprocessors