Objective: This study aimed to determine the concordance between the measurements of the airway dimensios present on the lateral cephalograms and computed tomography (GT) associated with obstructive sleep apnea (OSA) and to identify the association that could exist between anatomical variables measured on cephalograms and GT with AOS. Method: a concordance study were done in 31 subjects and a analytical observational study of cases and controls were realized in 305 adults between 25 and 74 years old, belonging to the Prevalence of sleep disorders and their relationship to cardiovascular risk conducted in Colombia at different altitudes program. All subjects underwent polysomnography for diagnosis of sleep disorders. This study was supported by the ethics committee of PUJ Faculty of Medicine and HUS|. In order to make the concordance study a cephalometric analysis was performed on the lateral cephalograms and this was correlated with cephalometric variables measured on CT, these measures were associated with the presence and absence of OSA. Subsequently, cephalometric variables measured in the TAG (the hyoid bone position and the maxillomandibular discrepancy) were associated with the presence and absence of AOS by an analytical observational case-control study. Results: In the concordance study: no correlation between lateral cephalograms and GT was found. In the association study of cephalometric variables with OSA no statistically significant correlation between measures of airway space on lateral cephalograms and CT with the presence of AOS were found. In the analytical case-control study: Class HE skeletal relationship was significantly associated with an opportunity to present AOS (OR - 2,76, 95% Cl = 1.36-5-57, p = 0.005), having an ascended hyoid bone position decreases the opportunity to present obstructive sleep apnea (OR - 0.40, 95% Cl = 0.19 to 0.82, P = 0,013). Conclusions: The lateral cephalograms and CT can identify anatomical regions associated with the presence of AOS but the concordance between these two diagnostic tests is poor.