Hybrid palm oil cross between the American palm {Elaeis oleifera) and African palm (Elaeis guineensis). Have been shown to possess high content of antioxidants and cardio protective compounds such as beta-carotene, tocopherols and tocotrienols. However, to date, there are no studies, which attempt to document the potential health effects of hybrid palm oil consumption in human subjects. Therefore, the aim of the present study was to determine in individuals over 50 years, after consuming 25 ml per day for three months, hybrid palm oil (experimental group) and extra-virgin olive oil (control group), the effects on the lipid profile (colorimetric method), plasma antioxidant capacity (methods: Folin Ciocalteu Reagent, RFC for phenolic compounds, oxygen radical absorbance capacity, ORAC and Trolox equivalent antioxidant capacity, TEAC) and changes in fatty acids, phospholipids and omega-3 index in the erythrocyte membrane, and compare to results of both groups. After consumption of oils, subjects of both groups showed significant decrease in total cholesterol and low density lipoprotein plasmatic level, together with an increased content of phenolic compounds and plasma antioxidant capacity. The total content of saturated fatty acids y index omega3 decreased in the erythrocyte membrane. Both oils showed comparable results (p> 0.05), suggesting that hybrid palm oil may can be considered as the tropical equivalent of extra-virgin olive oil and provide similar benefits on cardiovascular health.