This paper shows the evaluation of coordination scenarios in cancer drug supply networks using system dynamics. The current context and supply problems are described based on research conducted at healthcare service provider institutions (IPS) providing oncology services in different cities of Colombia. A review is conducted of the principal aspects related to coordination in supply systems. Two coordination scenarios are evaluated and analyzed based on the use of shared information together with decision making, utilizing reference parameters for high-cost medications that require adaptation in compounding centers (CCs) for the application of chemotherapy in patients with cancer. Results show close to 14% savings and around 98% compliance levels, which represents an important contribution to the Colombian healthcare system.