La apendicitis neonatal es una patologia infrecuente, de dificil diagnostico y con una mortalidad elevada. Se han estudiado diversas teorias sobre su etiologia que consideran que la apendicitis en el periodo neonatal podria corresponder a una manifestacion de inmadurez inmunitaria. El cuadro clinico de apendicitis en este grupo etareo no tiene las caracteristicas clasicas, incluyendo signos y sintomas inespecificos, que pueden corresponder a patologias mas frecuentes como la enterocolitis necrotizante. La perforacion intestinal constituye la complicacion mas frecuente y el diagnostico se realiza usualmente de forma intraoperatoria. En el presente articulo, se describen dos neonatos con diagnostico intraoperatorio de apendicitis, nacidos en la Clinica Universidad de La Sabana en el ano 2016. En ellos, se destaca el cuadro clinico de presentacion y manejo quirurgico, los cuales permitieron identificar esta patologia. Neonatal appendicitis: Two case reports Abstract Neonatal appendicitis is a rare condition, difficult to diagnose, and with a high mortality. Several hypotheses on its etiology have been postulated, since appendicitis in the neonatal period may correspond to a manifestation of immune immaturity. The clinical condition of appendicitis in this age group does not have the classic features, which include signs and nonspecific symptoms that may correspond to most frequent pathologies, such as necrotizing enterocolitis. Intestinal perforation is the most frequent complication and the diagnosis is usually intraoperative. The cases described in here correspond to two newborns with intraoperative diagnosis of appendicitis, delivered in the Universidad de La Sabana Clinic in 2016. Highlights on the aforementioned clinical condition are included. Surgical management, which allowed us to identify this pathology, was described.