We report an unusual case of mediastinal abcessed mass, with involvement of the lung, thymus and probably bone and hematopoietic system, in a newborn that was diagnosed with Langerhans cell histiocytosis. Its interest lies in the presentation as a rare cause of medias­tinal mass with involvement of other organs. Histologic exa­mination of the surgical specimen demonstrated Langerhans cell histiocytosis. It is known that vascular and lymphatic malformations, with teratomas, neurogenic tumors, lympha­denopathy of infectious origin and mediastinitis, are a major cause of mediastinal masses; in this case, it must also take into account the Langerhans Cell Histiocytosis as a cause. It had already reported cases of congenital solid masses neck and thigh as a unique presentation of this disease.