A comparative descriptive study was performed in order to compare the cephalometric measures in Grummons analysis between a two-dimensional digital image and a three dimensional image in patients with facial symmetry. Materials and Methods: A CT Cone Beam (CTCB) of the full skull and a postero-anterior (PA) digital x-ray was taken to ten patients with transverse asymmetry. In both images the Grummons Cephalometric analysis was applied. The measures taken at the CTCB were compared with measurements of PA radiographs, evaluating the level of agreement between measurements. Results: The measurement error for the CTCB was of 0.77 mm and for the PA radiograph was of 1.23 mm. Although for all measures, the differences between the two sides of the face were greater in the CTBC compared with the PA radiograph, only statistically significant differences were found for MSR-Ag and MSR-J (p <0.05) measures, which indicates that for these variables techniques significantly differ in measurement result. Conclusions: By applying the Grummons analysis in people without obvious or mild asymmetries, it was found that the use of two-dimensional images and/or three-dimensional generate similar measurements, i.e. the two techniques have similar accuracy. However, the location of some anatomical points, like the condilion one, becomes easier in the CTCB in regards with the PA radiograph, where the superimposition of structures makes difficult the precise location of the point.