Objective: To associate musculoskeletal disorders and ergonomic risk factors in nursing staff from a clinic in the Atlantic Coast, 2014. Materials and Methods: Descriptive-analytic study conducted with 111 nursing workers. The sociodemographic survey, Nordic (Spanish version) and a risk rating instrument according to physical activity were applied. Results: 73.9% of nursing staff in the institution are nursing assistants, 84.7% are women, with an average age of 30 years; 42.3% has been working at the clinic for less than a year and they work 41 to 60 hours a week on average (58.6%). 49.5% of nursing staff expressed muscular pains over the past 12 months, being back (37.8%) and neck (16.2%), the most affected parts of the body. During the working day, 39.6% carry weights higher than those permitted for men and women. There is significant association (p < 0.05) between the physical workload and the risk to show back symptoms (p = 0.036) or right hand-wrist troubles (p = 0.014). Conclusions: Back and right hand wrist pains are significantly associated (p < 0.05) to the physical workload risk.