Objectives: Evaluation of newborns with risk factors for developing neonatal sepsis at San Diego General Clinic in Barranquilla between February 2014 to December 2015, and the benefit of using prophylactic antibiotics as a prevention for neonatal sepsis. Methods: A prospective study was performed in which 155 cases were followed and analyzed, both with and without antibiotic prophylaxis, in patients with risk factors for sepsis to determine whether it affects morbidity or not. Analyzes were performed. Results: From a total of 4159 births, 155 new born (3.72 %) presented risk factors; antibiotics were used in 74 patients and in 81 patients there were no use of antibiotics