Neuroleptic malignant syndrome is a rare condition; manifestations include severe autonomic dysfunction, hyperthermia and muscle rigidity, among others. This may occur in response to drugs that interact with dopaminergic pathways. Diagnosis of this syndrome is mainly clinical since there is no specific laboratory test for this condition and it has a high mortality rate given its multiorgan involvement. This is a case report of a patient who developed neuroleptic malignant syndrome that was managed with supportive therapy and dantrolene.