Objective: To describe the clinical and demographic characteristics, the behavior of the disease and therapeutic outcome in our population with Recurrent Respiratory Papillomatosis (RRP) during the period 2006-2012. Materials and Methods: Descriptive study, observational case series, based on review of medical records of patients attended in 3 hospitals in Bogota, diagnosed with papilloma and confirmed by histopathology during the period between 2006 and 2012. Results: 100 patients were included in the study, the study population was 2 months to 83 years with an overall average of 39 years, 78% were male. 18 patients were children (JP) (10 children 55.6%, 8 girls: 44.4%) with age 8.9 +/- 4.6 years; 82 were adults (AP) (68 men: 82.9%, 14 women: 17.1%), mean age 45.6 +/-15.9 years. The age at diagnosis in the youth group was on average 6.01 +/- 4.6 years being younger than 2 months of life and in the adult group 40.9 +/- 17.2 years. 7% (2 pediatric patients, 5 adults) have required more than 10 interventions considered as aggressive forms of presentation. A specific pattern of spread of the disease was not documented. Was not possible to predict the time required for a new surgery. Bilateral involvement of the vocal cords was the most frequent with 65%, followed by lesions located in the anterior commissure by 52% and the posterior commissure in 25%. Tracheostomy was required in 3% of patients. 8% of patients had extralaryngeal dissemination. 25% had some form of laryngeal stenosis. All of them had in common the commitment of the anterior commissure. 21% had a premalignant/malignant lesion related to RRP. No patient was recorded without disease (cured), neither fatal cases were documented. Conclusions: The RRP has a spread and unpredictable behavior. It is vital to suspect this disease for early diagnosis and treatment. In light of current knowledge there is no ideal treatment. Always consider the risk of developing a stenosis both the disease or therapeutic modalities currently used. We documented the association between papillomavirus and a premalignant/malignant lesion is much larger than documented in the literature.