This article develops a theoretical reflection about the possible functions that can have the subject with respect to the relations of power and resistance. It uses initially to the notion of subjectificationas a referent in the ways in which the human being becomes subject and eventually becomes a node of resistance to power. Later addresses a unique form of resistance called desubjectificationand raised by Foucault from their analysis of the contemporary literary language; it is a typology of the modern “practices of self” implies not only a way to move beyond the idea of subject originating and self-sufficient knowledge, but also some emancipatory perspective the subject as a form of experience limit that seeks the detachment and the transformation of self.