This work presents a methodology for control structure design based on the Singular Value Decomposition (SVD) of the Hankel matrix, con- structed from the observability and controllability matrices. A weight index is proposed as a measure of the impact of each input and output variable and, based on it, an input-output pairing selection is per- formed. The methodology is validated using the Tennessee Eastman process and the result is com- pared to the relative gain method in frequency. Keywords Control structure design, SVD, Hankel matrix, Tennessee Eastman process.