The pyogenic granuloma is an excessive reaction against tissue irritants, such as dental calculus, foreign bodies and trauma, which stimulates the formation of an exuberant highly vascularized tissue. Often occurs on the gums, but may occasionally arise in other regions of the oral mucosa and skin. It is more common in the maxilla than the mandible. It affects individuals of various ages and both genders, with the peak incidence in the second and sixth decades of life, with a slight preponderance for females. The aim of this study is to report a case of pyogenic granuloma arose during pregnancy. Currently the patient is 10 months without recurrence.