This investigation proposed to validate, in problematic of innovation in contemporary context, the hypothesis of the emergency of innovation function in university and the identification of the factors that determine it as an expression of the educational communication. This context presents the configuration of networks between the diverse social actors determined by the way in which is transferred and applied the knowledge in the historical current epoch, provoking the need to understand the dynamics of this social learning. The complex interaction between university, innovation and regional development determines the conditions on which is emerging the innovation as the new misional function of university. This central problem of research comes out the comprehension of innovation as a matter of technical character and better in the dynamics of a process of educational communication between social actors. Conceptualization of innovation, national and regional innovation systems and innovation as educational communication, linked themselves to identify the different components derived from production and management of knowledge and the frame of the social sciences, what it implies in education, in the dynamics of production of knowledge, the society and economy of knowledge and its link with regional development that operates in the current globalization. Investigation was developed with the integrality of interaction between theoretical and methodological and the analysis of case to determine the degree and scope in which the university is experiencing a reconfiguration in his motional structure, inside the dynamics of response to the environment demands. The study of development plans of Technological University constituted the base of documentary analysis to confront the central thesis. The analysis of strategies and accomplishments of plans, the scope of projects and processes of innovation in which was compromised university, constituted the study of case to identify the reconfiguration of education - learning relations as one of the fundamental expressions of this misional restructuring of university.