The existence of network conditions between urban units comprising the “Ciudad region Eje Cafetero” is studied; from the current paradigm of the network of cities, which sees these as open organizations and in connection with their counterparts through interactions that occur in flows of people, goods and information. The identification of network relationships between cities is done through direct methods based on the analysis of the flow of people between the municipalities of the city region, and with the support of systems theory and application AGRAPH indicators are estimated by degree centrality, closeness and intermediation and from which evidence for the existence of this network and config