Se ha identificado en Colombia y otros paises el inadecuado uso de los antibioticos, lo cual aunado a la carencia de protocolos, ha ocasionado resistencia microbiana a los antibioticos y aumento en la mortalidad temprana. Estudios anteriores han podido identificar que uno de los factores que influyen en esta problematica, es el desconocimiento del perfil clinico y microbiologico de las infecciones. En este sentido, las investigadoras plantean la necesidad de realizar un estudio descriptivo, con el objeto de establecer el diagnostico etiologico (bacteriano, micotico o viral) y caracterizar la presentacion clinica de las sobreinfecciones en los pacientes con EPOC que ingresan a la UCI del hospital de Cartago y requieran via aerea artificial. La identificacion de las caracteristicas clinicas segun el agente causal, se realizara longitudinalmente, con un nivel de inferencia de plausibilidad, mediciones durante el tiempo de hospitalizacion del paciente y consulta de la historia clinica antigua y presente. Con este diseno se podra descartar el efecto de potenciales confusores y determinar con mayor confiabilidad el perfil clinico y microbiologico de las sobreinfecciones de la EPOC, en la poblacion objeto de estudio. Abstract Clinical - microbiological characterization patient pulmonary obstructive chronic disease sobreinfectada in uci departmental hospital of cartago It’s been identified that in Colombia and other countries, the use of antibiotics is inadequate due to the unknown Clinical-Microbiology Profile, as it’s shown in this specific research about over-infections in Chronic Obstructive-Pulmonary Disease’s Patients. All this combined with the lack of protocol, has lead to antibiotics resistance and to the increment of early patient’s death rate. The researches suggest the need to carry out the study of cases with the main objective of establishing an etiology diagnosis (bacterium, viral) and to characterize the clinical appearance of patient’s over-infection with chronic Obstructive-Pulmonary disease that are admitted in Cartago’s Hospital and need to be hospitalized in the Intensive Care Unit and that required an artificial respiratory track. The identification of clinical characteristics based on the causal agent will be done through a longitudinal descriptive study with a plausibly argument level, with assessments during the time the patient stays in the hospital and the checking of old and new patient’s medical records. With this pattern, we could avoid any confusion factors. Also, the clinicalmicrobiology profile about Chronic Obstructive-Pulmonary Disease overinfected, could be determined in the population in which the case studies are been developed. Keywords: chronic obstructive-pulmonary disease over-infected, virus, bacterium and fungus.