Clinical and pathological records of 21 pediatric patients with Infectious Endocarditis who were attended at the Hospital La Misericordia of Bogota, during 1986- 1993 were reviewed. Fifty two percent (52%) of the cases had clinical manifestation related to cardiovascular system involvement: changing murmur and congestive heart failure with fever, whereas clinical signs described in adults were not found; therefore it's necessary for diagnosis a high clinical suspicion. The valvular structural defects congenital or acquired (reumatic disease), are the main predisposing factors. Nevertheless intravenous catheters, immunosupression owed to malnutrition and septic states are also important predisponing factors. Tricuspid valve was the most frecuently affected structure and the etiologic agents were Slaphilococcus au reus and gram negatives. The mortality was similar to that reported in other series.