The case of a patient of 24 years who consulted for swollen ankles and erythema nodosum is presented. In conducting clinical and laboratory study of patient, Lofgren’s syndrome diagnosis was made, entity of low prevalence in our country. This case allows to make a discussion of the diagnosis of erythema nodosum and sarcoidosis. (Acta Med Colomb 2015; 40: 345-348).