Objective To know how prevention works on HIV mother-to-child transmission.Methods A survey was conducted to study the children with HIV+ mothers including children's medication taking after birth,feeding method,delivery method and ART for mothers to prevent mother-to-child transmission.Chi-square tests was implemented to see if children's infection rate differed between intervention group and control group.Results The infection rate of intervention group was 3.45%,while that of the control group was 15.38%.There was significant difference between these two groups.Conclusion Timely ART on pregnant mothers and their babies,intervention on artificial feeding,can effectively reduce HIV mother-to-child transmission rate.