The first objective of this article is to analyze some of the spatial interactions in the border zone shared by Brazil, Peru, and Bolivia, at the moment when the Interoceanic Highway connecting Brazil and Bolivia to the Pacific coast in Peru is completed. The second objective is to suggest that the classical geopolitical approach focused on great spaces (national subcontinental, and continental) and on government incentives should at least be complemented by the acknowledgement of the existence of a fragmented geopolitics, that is, of a geopolitical thought that targets small spaces and the small geopolitical game of governments and state agents. The study emphasizes the convenience of rethinking the concept of region, taking into account flexible borders and unstable spatial structures.