RESUMEN La cirugia micrografica de Mohs es el tratamiento quirurgico con mas altas tasas de curacion de los tumores malignos cutaneos agresivos localmente invasivos, minimizando el sacrificio innecesario de tejidos peritumorales sanos. Los margenes oncologicos son determinados en etapas sucesivas, los tejidos son evaluados en cortes histologicos horizontales en tres dimensiones, identificando con precision la localizacion de la persistencia oncologica subsecuente escision hasta la inexistencia del tumor respetando los tejidos sanos que no son removidos. MOHS MICROGRAPHIC SURGERY TREATMENT OF THE MALIGNANT CUTANEOUS TUMORS OF HIGH AGGRESSIVENESS AND COMPLEXITY (SECOND PART) ABSTRACT Mohs micrographic surgery is the surgical treatment with higher cure rates of aggressive locally invasive skin malignancies, minimizing unnecessary slaughter of healthy peritumoral tissues. Oncologic margins are determined in successive stages, tissues are evaluated in horizontal histological sections in three dimensions, precisely identifying the location of oncological subsequent cleavage persistence to the absence of tumor respecting healthy tissues are not removed .