Bud Rot complex (BR) is the major disease of oil palm in Colombia. In the Central (ZC) and Eastern (ZE) oil palm regions, palms affected by BR are able to naturally recover. In the Western Region (ZW) the recovery process is not evident. Recovery of the palms is linked to high meristem activity, which could involve the promoting action of plant growth regulators such as polyamines (PA). This study shows the relationship between polyamine content and the capacity of palms to recover from BR in two regions with different agroclimatic conditions. Polyamines extracted from palms planted on ZC and ZW were analyzed by HPLC. On ZC where spontaneous recovery is present, the highest values were measured on healthy and recovery palms and with the progression of the disease, PA concentration decreased reaching a minimum point in the initial BR stage. From this point, PA concentration gradually increased until the Good Recovery stage in which PA values where higher than those found on healthy palms. In ZW, PA content increased with the disease, reaching the highest value in the affected palms without recovery, with the lowest values measured on healthy palms. The differences between regions might be related to the different roles polyamines play on plants. In ZC the increased amount of PA in healthy palms or in palms under recovery could have a major role in meristem activity induction, required for the spontaneous recovery. In the ZW, the increased of PA content with the disease could be related to the production of reactive oxygen species as a plant secondary defense mechanism due to the impossibility for the plants to, through the increment on meristem activity as the observed in the Central region, produce healthy structures which are not re-infected.