Proteins containing a TIR domain (Toll Interleukin Receptor) are involved in plant and animal immunity. The aim of this work was to carry out an overall genomic analysis of cassava proteins with a TIR domain and discern their possible role in resistance to cassava bacterial blight. In total 46 proteins with a TIR domain were identified in the cassava proteome and were classed in four categories according the presence or absence of other domains: TIR (T), TIR-NB (TN), TIR-LRR (TL) and TIR-NB-LRR (TNL). 56.6 %