The consumption of licit and illicit drug use among university students of U.D.C A, under a descriptive, observational and cross-sectional design, in a sample of 128 students was investigated. The instrument used was the questionnaire applied in the II Andean epidemiological study on drug use in the student population of 2012 and the Test of disorders related to alcohol consumption (AUDIT). The main results show that the most consumed substances are alcohol, snuff and marijuana; social determinants of consumption are associated with the accessibility, supply and opportunity to test drugs for illicit use, like curiosity and the consumption of these substances by friends. As a protective factor saying No to the consumer opportunity was identified. The active participation of the University in health promotion programs, based on the formation of a critical and independent young facing the supply and consumption of psychoactive substances is recommended