Venous Sinus thrombosis is an important disease, for recognizing it can be difficult, as the clinical picture may be very diverse. It is an uncommon cause of brain infarction when comparing it to that of arterial origin, which has a great morbility. It may cause death in 10% of the cases in which it blossoms. In the following article, the clinical case of a patient with migraine with aura who was in therapy with oral contraceptives three months ago is described. The patient seeked medical attention due to an unusual crisis of her migraine; later, with the help of a contrasted brain Angioresonance, a left transverse sinus thrombosis diagnosis was performed. Anticoagulation treatment is started with low molecular weight heparin and the disease evolution is favorable and she was remitted to assessment by gynecology to establish treatment of polycystic ovary. On behalf of this case, the authors present a review on diagnosis and focus of cerebral venous sinus thrombosis and it’s association with migraine.